Molecular identity , ontogeny , and cAMP modulation of the hyperpolarization - activated 1 current in vestibular ganglion neurons
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چکیده
1 current in vestibular ganglion neurons. 12 AA and EL made the electrophysiological recordings. FM made the PCR analysis. ES 13 and RV did the immunohistochemical experiments. Abstract 29 Properties, developmental regulation and cAMP modulation of the hyperpolarization
منابع مشابه
Molecular identity, ontogeny, and cAMP modulation of the hyperpolarization-activated current in vestibular ganglion neurons.
Properties, developmental regulation, and cAMP modulation of the hyperpolarization-activated current (I(h)) were investigated by the whole cell patch-clamp technique in vestibular ganglion neurons of the rat at two postnatal stages (P7-10 and P25-28). In addition, by RT-PCR and immunohistochemistry the identity and distribution of hyperpolarization-activated and cyclic nucleotide-gated channel ...
متن کاملIdentification and modelling of fast and slow Ih current components in vestibular ganglion neurons.
Previous experimental data indicates the hyperpolarization-activated cation (Ih) current, in the inner ear, consists of two components [different hyperpolarization-activated cyclic nucleotide-gated (HCN) subunits] which are impossible to pharmacologically isolate. To confirm the presence of these two components in vestibular ganglion neurons we have applied a parameter identification algorithm ...
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The hyperpolarization-activated, cyclic nucleotide-sensitive current, Ih, is present in vestibular hair cells and vestibular ganglion neurons, and is required for normal balance function. We sought to identify the molecular correlates and functional relevance of Ih in vestibular ganglion neurons. Ih is carried by channels consisting of homo- or heteromeric assemblies of four protein subunits fr...
متن کاملExpression of a functional hyperpolarization-activated current (Ih) in the mouse nucleus reticularis thalami.
The GABAergic neurons of the nucleus reticularis thalami (nRT) express the type 2 hyperpolarization-activated cAMP-sensitive (HCN2) subunit mRNA, but surprisingly, they were reported to lack the hyperpolarization-activated (Ih) current carried by this subunit. Using the voltage-clamp recordings in the thalamocortical slice preparation of the newborn and juvenile mice (P6-P23), we demonstrate th...
متن کاملPostnatal maturation of the hyperpolarization-activated cation current, I(h), in trigeminal sensory neurons.
Hyperpolarization-activated inward currents (I(h)) contribute to neuronal excitability in sensory neurons. Four subtypes of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels generate I(h), with different activation kinetics and cAMP sensitivities. The aim of the present study was to examine the postnatal development of I(h) and HCN channel subunits in trigeminal ganglion (TG) n...
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تاریخ انتشار 2012